70 Questions
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Genetics Biology Part 1 : Mendelian Genetics, Post-Mendelian Genetics & Chromosomal Theory
Medical Science Q&A
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70
Questions
19
Easy
35
Medium
16
Hard
Showing 70 of 70 questions
1
EasyGEN-001
Gregor Mendel is called the 'Father of Genetics'. He conducted his experiments on which plant?
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2
EasyGEN-002
In a monohybrid cross between tall (TT) and dwarf (tt) pea plants, what is the phenotypic ratio in F2 generation?
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3
EasyGEN-003
In Mendel's dihybrid cross (RRYY × rryy), what is the F2 phenotypic ratio?
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4
MediumGEN-004
Mendel's Law of Independent Assortment holds true only when genes are located on:
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5
MediumGEN-005
In incomplete dominance, the F2 ratio of phenotype and genotype is:
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6
MediumGEN-006
Co-dominance differs from incomplete dominance in that:
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7
EasyGEN-007
ABO blood group system is an example of which genetic phenomenon?
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8
MediumGEN-008
A man with blood group A (Iᴬi) marries a woman with blood group B (Iᴮi). What are the possible blood groups of their children?
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9
MediumGEN-009
Pleiotropy refers to:
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10
EasyGEN-010
T.H. Morgan's experimental organism for genetics was:
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11
MediumGEN-011
Linkage is defined as the tendency of genes located on the same chromosome to:
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12
MediumGEN-012
Crossing over occurs between which cells and at which stage?
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13
EasyGEN-013
Sex determination in humans — which parent determines the sex of the child?
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14
MediumGEN-014
In honey bees, sex is determined by:
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15
EasyGEN-015
Haemophilia A is caused by deficiency of which clotting factor and what is its inheritance pattern?
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16
MediumGEN-016
A carrier female for haemophilia (X^H X^h) marries a normal male (X^H Y). What is the probability of their son being affected?
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17
EasyGEN-017
Down's syndrome (Trisomy 21) is characterized by:
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18
MediumGEN-018
Turner's syndrome karyotype is:
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19
MediumGEN-019
Klinefelter's syndrome (47,XXY) presents with which features?
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20
MediumGEN-020
Barr body is derived from:
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21
HardGEN-021
Sickle cell anemia is caused by a point mutation in the beta-globin gene. What is the specific amino acid change?
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22
MediumGEN-022
Phenylketonuria (PKU) is caused by deficiency of which enzyme and has which inheritance pattern?
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23
EasyGEN-023
In a test cross (back cross), a phenotypically dominant individual is crossed with:
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24
HardGEN-024
What is epistasis?
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25
MediumGEN-025
Polygenic inheritance controls which human traits?
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26
MediumGEN-026
Non-disjunction occurs during which process and what are its consequences?
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27
MediumGEN-027
Maternal age effect: risk of Down syndrome increases significantly after maternal age of:
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28
HardGEN-028
Sex-linked vs sex-limited vs sex-influenced traits — which is correct?
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29
MediumGEN-029
Colour blindness (red-green) is an X-linked recessive trait. If a colour-blind woman marries a normal man, what will be the outcome for their children?
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30
EasyGEN-030
Which of the following correctly pairs a chromosomal disorder with its karyotype?
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31
MediumGEN-031
The concept of 'gene' was initially proposed by which scientist?
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32
EasyGEN-032
What is the phenotypic ratio when both parents are heterozygous for an autosomal recessive condition (Aa × Aa)?
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33
MediumGEN-033
Colour blindness (X-linked recessive) in a family where father is colour blind and mother is homozygous normal (X^N X^N). What will be the outcome?
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34
MediumGEN-034
If two genes are 20 map units apart, what percentage of offspring will show recombinant phenotypes?
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35
HardGEN-035
What is a lethal allele? Give an example.
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36
EasyGEN-036
Which of the following is a sex-linked trait in humans?
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37
HardGEN-037
Duchenne Muscular Dystrophy (DMD) is caused by which gene defect?
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38
HardGEN-038
Huntington's disease (HD) is an example of which type of genetic disorder?
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39
MediumGEN-039
Mitochondrial inheritance has which unique feature?
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40
MediumGEN-040
The Hardy-Weinberg principle states that in a large, random-mating population WITHOUT evolutionary forces, allele and genotype frequencies will remain:
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41
HardGEN-041
Using Hardy-Weinberg equation: If the frequency of albinism (aa) in a population is 1/10,000 (0.0001), what is the carrier frequency?
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42
MediumGEN-042
Genetic drift is most significant in which type of population?
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43
HardGEN-043
Genomic imprinting is a phenomenon where:
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44
MediumGEN-044
A pedigree analysis shows that a trait appears in every generation, affects both males and females equally, and every affected person has an affected parent. This suggests:
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45
EasyGEN-045
Mutation in which type of cell is heritable and can be passed to offspring?
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46
HardGEN-046
What is penetrance in genetics?
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47
EasyGEN-047
What is a pedigree chart and what do the symbols represent?
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48
EasyGEN-048
Which of the following is an example of continuous variation?
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49
HardGEN-049
What is concordance rate in twin studies and what does it tell us about genetics vs environment?
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50
MediumGEN-050
Consanguineous marriages increase the risk of which type of genetic disorders in offspring?
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51
MediumGEN-051
How many types of gametes are produced by an individual with genotype AaBbCc?
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52
MediumGEN-052
How many different phenotypes appear in the F2 generation of a dihybrid cross (AaBb × AaBb) with complete dominance?
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53
EasyGEN-053
In Mendel's experiments, when he crossed tall and dwarf plants (TT × tt), the F1 plants when self-pollinated produced what ratio?
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54
MediumGEN-054
Cytoplasmic inheritance (extra-nuclear inheritance) is due to genes in which organelles?
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55
EasyGEN-055
In Mendel's cross experiment, which of the seven characters he studied showed a ratio of 3:1 in F2?
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56
HardGEN-056
Cystic fibrosis (CF) gene mutation — which is the most common mutation?
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57
MediumGEN-057
An individual's genotype is AaBbcc. How many phenotypically different offspring types are produced when crossed with AaBbcc?
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58
MediumGEN-058
Cri du Chat syndrome ('cat cry syndrome') is caused by:
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59
MediumGEN-059
What are the principles underlying Mendel's laws at the chromosomal level?
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60
HardGEN-060
Recombination frequency between two genes is found to be 50%. What does this indicate?
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61
HardGEN-061
Translocation Down's syndrome differs from standard Trisomy 21 in that:
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62
EasyGEN-062
Which of the following best describes the 'Central Dogma of Molecular Biology'?
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63
HardGEN-063
What is anticipation in genetics and give an example?
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64
HardGEN-064
Which enzyme is responsible for DNA replication in Escherichia coli?
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65
MediumGEN-065
Semiconservative replication of DNA was proven by which experiment?
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66
HardGEN-066
What is the Lac operon and what type of regulation does it represent?
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67
MediumGEN-067
Human Genome Project (HGP) — major findings and significance:
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68
MediumGEN-068
DNA fingerprinting (DNA profiling) uses which technique and application:
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69
MediumGEN-069
Natural selection acts on phenotype. What is the RAW MATERIAL for natural selection?
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70
EasyGEN-070
Evidence for evolution includes: which of the following is the BEST direct evidence?
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