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Showing 70 of 70 questions
1
EasyMOL-001
Watson and Crick proposed the double helix model of DNA in which year and journal?
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2
EasyMOL-002
Chargaff's rules state that in any DNA sample:
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3
HardMOL-003
If one strand of DNA has base composition: A=30%, T=20%, G=25%, C=25%. Is this consistent with Chargaff's rules for DOUBLE-STRANDED DNA?
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4
MediumMOL-004
DNA packaging in eukaryotes: the basic structural unit of chromatin is:
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5
EasyMOL-005
The 'Search for Genetic Material' — Griffith's transformation experiment (1928) demonstrated:
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6
EasyMOL-006
The purine bases in DNA are:
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7
MediumMOL-007
In DNA replication, Okazaki fragments are formed on which strand and why?
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8
HardMOL-008
Telomeres and telomerase — what is the 'end replication problem' and how is it solved?
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9
MediumMOL-009
In transcription, which strand of DNA is used as the template?
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10
MediumMOL-010
The genetic code is described as 'degenerate.' What does this mean?
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11
EasyMOL-011
What are the THREE stop codons and ONE start codon?
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12
MediumMOL-012
Properties of the genetic code — which property states the genetic code is the SAME in all living organisms?
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13
MediumMOL-013
tRNA structure — which part of tRNA carries the amino acid and which recognizes the codon?
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14
MediumMOL-014
The ribosome has three sites for tRNA binding. What are they?
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15
MediumMOL-015
What are introns and exons, and what process removes introns from pre-mRNA?
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16
HardMOL-016
mRNA processing in eukaryotes involves three main modifications. What are they?
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17
HardMOL-017
RNA polymerase in prokaryotes — what subunits does it have and what is the function of sigma factor?
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18
MediumMOL-018
Reverse transcriptase is an enzyme found in retroviruses. What does it do?
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19
EasyMOL-019
PCR (Polymerase Chain Reaction) — what are the three steps and what enzyme is used?
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20
MediumMOL-020
CRISPR-Cas9 gene editing — which scientist won the Nobel Prize and in which year?
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21
HardMOL-021
DNA fingerprinting by RFLP (Restriction Fragment Length Polymorphism) uses which enzymes?
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22
MediumMOL-022
Transposons ('jumping genes') were discovered by which scientist?
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23
MediumMOL-023
Beadle and Tatum's 'One Gene, One Enzyme' hypothesis was established using which organism?
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24
HardMOL-024
RNA world hypothesis states that:
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25
EasyMOL-025
Miller-Urey experiment (1953) demonstrated:
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26
MediumMOL-026
What is the Modern Synthetic Theory (Neo-Darwinism) of evolution?
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27
EasyMOL-027
Homologous structures are evidence for which type of evolution?
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28
EasyMOL-028
Industrial melanism (peppered moth — Biston betularia) is an example of:
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29
MediumMOL-029
Adaptive radiation refers to:
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30
MediumMOL-030
Speciation is defined as:
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31
HardMOL-031
Epigenetics refers to:
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32
MediumMOL-032
Somatic cell hybridization (Protoplast fusion) is used for:
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33
HardMOL-033
What is a viroids — and which disease does it cause?
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34
EasyMOL-034
Recombinant DNA technology — which enzyme is used to JOIN DNA fragments?
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35
EasyMOL-035
What is gel electrophoresis and what does it separate?
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36
HardMOL-036
What is the Trp operon (tryptophan operon) and how does it differ from the Lac operon?
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37
HardMOL-037
What is the 'nucleosome free region' (NFR) at promoters and why is it important?
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38
EasyMOL-038
DARWIN and his theory of natural selection — what were the observations that led to his theory?
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39
EasyMOL-039
Lamarck's theory of evolution was based on which incorrect principle?
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40
MediumMOL-040
Bt cotton — how does it work and what gene does it contain?
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41
MediumMOL-041
What is the difference between prokaryotic and eukaryotic ribosomes?
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42
HardMOL-042
What is a mutation? Classify types of point mutations.
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43
MediumMOL-043
What is the significance of palindromic sequences in DNA for restriction enzymes?
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44
HardMOL-044
What are Hox genes and what is their significance in development and evolution?
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45
MediumMOL-045
Phylogenetics uses which type of evidence to classify and determine evolutionary relationships?
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46
HardMOL-046
DNA methylation at CpG dinucleotides: what happens when promoter CpG islands are methylated?
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47
MediumMOL-047
What are restriction fragment length polymorphisms (RFLP) and how are they detected?
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48
HardMOL-048
What is the lac operon (lacI) — the role of the repressor and operator?
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49
HardMOL-049
The 'mRNA properties' — what is the half-life of mRNA and what factors affect its stability?
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50
EasyMOL-050
Summary question: Which Nobel Prize was awarded in 1962 for DNA double helix structure?
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51
HardMOL-051
In translation, what is the function of peptidyl transferase?
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52
EasyMOL-052
What is a 'naked DNA' experiment in transformation and why is it significant?
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53
HardMOL-053
What is the Shine-Dalgarno sequence and what is its role?
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54
HardMOL-054
What is the 'Meselson-Stahl experiment' result at generation 2 and what does it prove?
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55
EasyMOL-055
In a DNA molecule, if Guanine is 24%, what is the percentage of Thymine?
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56
MediumMOL-056
An mRNA has the sequence 5'-AUGCAGCUAUGA-3'. How many amino acids will be in the resulting polypeptide (not counting the initiator Met)?
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57
EasyMOL-057
If a double-stranded DNA molecule has 20% Adenine, what is the number of Guanine + Cytosine nucleotides if total nucleotides are 1000?
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58
MediumMOL-058
E. coli genome versus human genome — key differences:
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59
MediumMOL-059
Which of these viruses is an RNA virus?
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60
MediumMOL-060
What is the effect of a frameshift mutation on a protein?
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61
HardMOL-061
Gene therapy — what is it and what are the two main types?
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62
MediumMOL-062
Which enzyme catalyzes the synthesis of an RNA primer during DNA replication?
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63
HardMOL-063
Eukaryotic gene regulation — what are enhancers and how do they work?
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64
MediumMOL-064
Which organelle provides evidence for the endosymbiotic theory of eukaryotic evolution?
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65
EasyMOL-065
What is the total number of codons in the genetic code, and how many code for amino acids vs stop codons?
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66
MediumMOL-066
Recombinant insulin production — which organism is used and what was the significance?
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67
HardMOL-067
Gene expression in eukaryotes — post-transcriptional regulation by miRNA:
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68
HardMOL-068
Chromosomal basis of cancer — what are PROTO-ONCOGENES and how do they become ONCOGENES?
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69
HardMOL-069
What is polyploidy and why is it important in plant evolution and agriculture?
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70
MediumMOL-070
What is Darwinian fitness in population genetics?
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