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HISTOPATHOLOGY-69
CELLULAR SENESCENCE refers to a state where cells PERMANENTLY STOP DIVIDING but remain metabolically active. Which mechanism is PRIMARILY responsible for replicative senescence?
A. Accumulation of lipofuscin in the cytoplasm
B. Progressive TELOMERE SHORTENING with each cell division until a critical length triggers senescence
C. Increase in mitochondrial number beyond cellular capacity
D. Accumulation of apoptotic cells in tissues
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