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Question 269 / 312
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VIRO-102
Oseltamivir MECHANISM and RESISTANCE — how does oseltamivir work and which mutation causes resistance?
A. Oseltamivir inhibits hemagglutinin; K103N mutation causes resistance
B. OSELTAMIVIR (neuraminidase inhibitor): binds active site of NEURAMINIDASE enzyme; PREVENTS CLEAVAGE of sialic acid from host cells; newly assembled virions TRAPPED on cell surface; CANNOT SPREAD to neighboring cells; RESISTANCE: H275Y MUTATION (histidine to tyrosine at position 275) in neuraminidase N1 gene; resistant strains treated with ZANAMIVIR or BALOXAVIR
C. Oseltamivir inhibits RNA polymerase; M2 channel mutation causes resistance
D. Oseltamivir prevents viral entry; M184V mutation causes resistance
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